Cellular mechanism of action of cardiac glycosides

Question of norepinephrine release in the action of cardiac glycosides.

Contraction dependency of the positive inotropic action of cardiac glycosides.

The concept that the positive inotropic effect of cardiac glycosides is dependent on the contractile state of the myocardium was tested. Isolated left atria of rabbits, when driven electrically at 15, 30, 60 and 120/min (at 30, 33, or 37°C), responded to ouabain (1 yug/ml) in proportion to the number of contractions and not to the time of exposure or frequency of drive. Contraction-related effe...

The action of cardiac glycosides on experimental auricular flutter.

Mechanism of Action of the Thyroid Hormone on the Heart

SUMMARY  The foliowing cardiac effects may be at­tributed to thyroxin:  1-Thyroxin augments all anaerobic pro­cesses in the body includ::ng the heart, and decreases the glycogen content of the heart ( 1, 2, 5, 27). The resistance of the heart to anoxia is increased in hyperthyroidism ( 25). 2- Thyroxin influences the cardiac weight and prevents cardiac atrophy (3, 8, 10, 11, 19, 20, 21, 30...

Antibacterial Activity of Polypyrrole-Chitosan Nanocomposite: Mechanism of Action

Polypyrrole-chitosan nanocomposite (PPy-CTN) was synthesized by dispersion polymerization of PPy in presence of CTN. Preparation of spherical PPy nanoparticles that were successfully covered with a thin layer of chitosan was confirm by transmission electron microscopy (TEM) technique. Characterization techniques also revealed the presence of CNT in the polymer matrix and its presence was confir...